Reproductive hormone protects against cardiac diseases: Relaxin-based therapy for Cardiomyopathy:  Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via up-regulation of its target gene, 23/August/2018, 2.54 pm

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This study was published, in the 2 June  2015 issue of the journal “Nature Genetics” (the number 1 research journal in Genetics with an impact factor of 29.648), by Prof. Da-Zhi Wang & Jian Ding, and […]

A Lotus way to lengthen lifespan: The Lotus component Nucinferin-based therapy for life-span extension: Nucinferin, isolated from lotus leaf, may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 23/August/2018, 2.36 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of […]

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  HNF4α, CADM2, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 22/August/2018, 7.48 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]

Combinatorial  therapy for human cancers: A pharmaceutical mixture encompassing Metformin, Berberine, Despiramine, 17-AAG, Curcumin, Calcitriol, Capsaicin, Camptothecin, Simvastatin, Salinomycin, (MBDAAGCCCSS) inhibits the expression of KAT6A and KAT6B, increases the expression of INK4a/ARF and other genes, promotes senescence, prevents cancer recurrence, and prolongs survival, via up-regulation of its target gene, 22/August/2018, 7.35  am

Introduction: What they say: A study from the Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia; and Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia shows that “Inhibitors of histone acetyltransferases KAT6A/B induce senescence and […]

Combinatorial therapy for Metastatic ovarian cancers: A therapeutic mix encompassing  Metformin, 17-AAG, Carboplatin, Despiramine, Simvastatin, and Salinomycin (MAAGCDSS) inhibits the expression of FABP4, increases the expression of a number of tumor suppressor genes, and stifles the metastatic potential and the progression of ovarian cancers, via up-regulation of its target gene, 22/August/2017, 7.21 am

Introduction: What they say: A study from the Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA shows that “FABP4 as a key determinant of metastatic potential of ovarian cancer” This study was published, in the 26 July 2018 issue of the journal “Nature communications” […]

Molecular therapy for cardiomyocyte proliferation and heart regeneration: Nucleolin, a nucleolar protein, decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 22/August/2018, 7.07 am

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China; and Department of Pathology and Laboratory Medicine, University […]