Ideas

The female steroid hormone functions as a longevity promoter: 17α-Estradiol (trade name: Avicis, Avixis, Ell-Cranell Alpha, and Pantostin), the c-17 epimer of Estradiol,  may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 22/August/2018, 6.31 am
The female steroid hormone functions as a longevity promoter: 17α-Estradiol (trade name: Avicis, Avixis, Ell-Cranell Alpha, and Pantostin), the c-17 epimer of Estradiol,  may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 22/August/2018, 6.31 am 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology,…

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Consuming olive oil may prolong your lifespan and healthspan: Oleic acid, one of the components of Olive oil, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 22/August/2017, 6.27 am
Consuming olive oil may prolong your lifespan and healthspan: Oleic acid, one of the components of Olive oil, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 22/August/2017, 6.27 am 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  RECK, CADM1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 20/August/2018, 7.32 pm
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  RECK, CADM1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 20/August/2018, 7.32 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Molecular therapy for Myocardial infarction: Nucleolin, a nucleolar phosphoprotein that plays a role in the maturation of ribosomes,  inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 20/August/2018, 7.21 pm
Molecular therapy for Myocardial infarction: Nucleolin, a nucleolar phosphoprotein that plays a role in the maturation of ribosomes,  inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 20/August/2018, 7.21 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of the journal Nature,  by Prof Dimmler, Boon, and…

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Combinatorial  therapy for human cancers: A pharmaceutical mixture encompassing Curcumin, Calcitriol, Amitriptyline, 17-DMAG, Temozolomide Berberine, Rosuvastatin, Salinomycin, (CCADTBRS) inhibits the expression of KAT6A and KAT6B, increases the expression of INK4a/ARF and other genes, promotes senescence, prevents cancer recurrence, and prolongs survival, via up-regulation of its target gene, 20/August/2018, 7.04  am
Combinatorial  therapy for human cancers: A pharmaceutical mixture encompassing Curcumin, Calcitriol, Amitriptyline, 17-DMAG, Temozolomide Berberine, Rosuvastatin, Salinomycin, (CCADTBRS) inhibits the expression of KAT6A and KAT6B, increases the expression of INK4a/ARF and other genes, promotes senescence, prevents cancer recurrence, and prolongs survival, via up-regulation of its target gene, 20/August/2018, 7.04  am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; The Walter and Eliza Hall Institute of Medical Research,…

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Repurposing the anti-angina drug Ranolazine into a diabetes retinopathy drug: A pharmaceutical mixture encompassing Ranolaxine, Epicatechin and Matrine (REM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 20/August/2018, 12.05 am
Repurposing the anti-angina drug Ranolazine into a diabetes retinopathy drug: A pharmaceutical mixture encompassing Ranolaxine, Epicatechin and Matrine (REM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 20/August/2018, 12.05 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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