Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others, increases the expression of tumor suppressors genes, such as Navigator(Nav3), HBP-1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 19/August/2018, 11.55 pm
From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]
Revealing the unrevealed function of the reproductive hormone Relaxin in triglycerides/cholesterol reduction and in the treatment of Non-alcoholic fatty liver disease (NAFLD) : Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of NAFLD, via down-regulation of its target gene, 19/August/2018, 11.45 pm
The significance of the study: Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD; and (4) the global economic […]
Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 19/August/2017, 11.23 pm
What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C, and others. What […]
Revealing the unrevealed function of the reproductive hormone Relaxin in the heart: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 19/August/2018, 12.35 am
What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of the journal Nature, by Prof Dimmler, Boon, and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Revealing the unrevealed function of the reproductive […]
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others, increases the expression of tumor suppressors genes, such as Smad7, p12DOC1/CDK2AP1, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 19/August/2018, 12.13 am
From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant […]
Reproductive hormone aids in the treatment of blood sugar disease: Relaxin-based therapy for DM: Relaxin, a reproductive hormone, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of its target gene Lin28, 19/August/2018, 12.07 am
Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological Sciences, with an I.F of 28.71], by Prof George Q, the present Dean […]