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Ideas

March 18, 2018

A candy way to treat Non-alcoholic fatty liver disease: Sugar-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Mannose, a C-2 epimer of glucose, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 18/March/2018, 8.51 am

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
March 18, 2018

Rare Sugar-based therapy for Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors PTEN and PDCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 18/March/2018, 8.35 am

From Significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
March 17, 2018

A candy way to extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener in drugs, confections, toothpaste, and chewing gum, may increase life span, via up-regulation of its target gene BubR1, 17/March/2018, 9.01 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
March 17, 2018

A candy way to treat blood sugar disease: Sugar-based therapy for autoimmune diabetes (TIDM): D-Mannose, a C-2 epimer of glucose, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 17/March/2018, 8.28 am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and […]
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