Ideas

A flu vaccine-based therapy for lowering cholesterol, and triglycerides levels: Repurposing Influenza A/flu(H1N1) vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): Influenza A/flu(H1N1) vaccine decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via down regulation of its target gene, 12/July/2018, 1.04 pm
A flu vaccine-based therapy for lowering cholesterol, and triglycerides levels: Repurposing Influenza A/flu(H1N1) vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): Influenza A/flu(H1N1) vaccine decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via down regulation of its target gene, 12/July/2018, 1.04 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in…

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A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others,  may  increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes, 12/July/2018, 12.53 pm
A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others,  may  increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes, 12/July/2018, 12.53 pm 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Flu vaccine comes to the rescue of blood sugar disease: Influenza A (H1N1) vaccine-based regenerative therapy for reversing diabetes:  Influenza A (H1N1) vaccine increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D, via down regulation of its target gene, 12/July/2018, 12.37 pm
Flu vaccine comes to the rescue of blood sugar disease: Influenza A (H1N1) vaccine-based regenerative therapy for reversing diabetes:  Influenza A (H1N1) vaccine increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D, via down regulation of its target gene, 12/July/2018, 12.37 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute…

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Heat shock protein inhibitors as longevity-promoters: 17-DMAG, an HSP(heat shock protein)-90 inhibitor,  increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan, via down regulation of its target gene, 12/July/2018, 12.20 pm
Heat shock protein inhibitors as longevity-promoters: 17-DMAG, an HSP(heat shock protein)-90 inhibitor,  increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan, via down regulation of its target gene, 12/July/2018, 12.20 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann…

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Turning on the cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as CADM1, RECK, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 9/July/2018, 11.51 am
Turning on the cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as CADM1, RECK, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 9/July/2018, 11.51 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Insulate your heart against cardiac dysfunction with flu vaccine: Influenza A (H1N1) vaccine-based adjunct therapy for cardiac hypertrophy and fibrosis: Influenza A (H1N1)/Flu vaccine decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 9/July/2018, 11.41 am
Insulate your heart against cardiac dysfunction with flu vaccine: Influenza A (H1N1) vaccine-based adjunct therapy for cardiac hypertrophy and fibrosis: Influenza A (H1N1)/Flu vaccine decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 9/July/2018, 11.41 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich…

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