Ideas

December 11, 2017

Combinatorial therapy for body weight control, energy homeostasis and TIIDM: A pharmaceutical mixture encompassing Trimetazidine (TMZ) and Astaxanthin (ATX) [TMZATX]  increases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 11/December/2017, 10.32 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell […]
December 10, 2017

Molecular therapy for heart regeneration and repair: A therapeutic mix encompassing Trimetazidine (TMZ) and Astaxanthin (ATX) [TMZATX]  increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 10/December/2017, 10.45 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
December 10, 2017

Natural product-based therapy for body weight control, energy homeostasis and TIIDM: Carvedilol[Trade name: Coreg], Nonselective beta/alpha1 blocker used in the treatment of myocardial dysfunction and hypertension, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/December/2017, 9.59 am

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]
December 10, 2017

Activation of the PD-1 pathway for Pain therapy: Punicalagin, isolated from Pomegranate,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 10/December/2017, 7.13 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]