Ideas

November 13, 2018
Published by admin_auro at November 13, 2018
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Repurposing the anti-epileptic drug Valproic acid into an anti-diabetic (autoimmune) drug: Valproic acid (brand name: Convulex, Depakote, Epilim, Stavzor), a medication used to treat epilepsy and bipolar disorder and to prevent migraine headaches, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 13/november/2018, 11.59 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
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November 13, 2018
Published by admin_auro at November 13, 2018
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Molecular therapy for Myocardial Infarction: AP-1 (Activator protein-1) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 13/November/2018, 11.28 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]
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November 13, 2018
Published by admin_auro at November 13, 2018
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Cancer therapy targeting cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, increases the expression of tumor suppressor genes, such as HNF4α, CADM2, p53, and TA-p73/p63, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 13/November/2018,11.20 pm

Introduction: What they say: A study from the Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA shows […]
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November 12, 2018
Published by admin_auro at November 12, 2018
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Probiotic-based therapy for Acute Myeloid Leukemia: Lactobacillus rhamnosus decreases the expression of BCLAF1,  promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 12/August/2018, 10.40 pm

Introduction: What they say: A study from the Institute of Genetics and Biophysics, CNR, Naples, Italy; and Department of Biochemistry, Biophysics and General Pathology, Second University […]
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