Ideas

November 13, 2018

Published by admin_auro at November 13, 2018

Categories

Cancer therapy targeting cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, increases the expression of tumor suppressor genes, such as HNF4α, CADM2, p53, and TA-p73/p63, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 13/November/2018,11.20 pm

Introduction: What they say: A study from the Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA shows […]

November 12, 2018

Published by admin_auro at November 12, 2018

Categories

Cancer
Ideas

Probiotic-based therapy for Acute Myeloid Leukemia: Lactobacillus rhamnosus decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 12/August/2018, 10.40 pm

Introduction: What they say: A study from the Institute of Genetics and Biophysics, CNR, Naples, Italy; and Department of Biochemistry, Biophysics and General Pathology, Second University […]

November 12, 2018

Published by admin_auro at November 12, 2018

Categories

Mechanistic insights into how Aliskiren functions as a learning/memory/cognitive-enhancer: Aliskiren (brand name: Tekturna and Rasilez) ), a renin inhibitor used in the treatment of essential hypertension, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 12/November/2018, 9.42 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA; Paul F. Glenn Center […]

November 12, 2018

Published by admin_auro at November 12, 2018

Categories

Molecular therapy for cardiac dysfunction: Candisartan, an angiotensin II receptor antagonist used in the treatment of hypertension and congestive heart failure, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 12/November/2018, 9.06 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]