Ideas

Molecular therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing   3,3′-Diindolylmethane (DIM) Sodium nitrite(NaNO2), and  Sodium Sulfide (DIMSNSS) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 20/May/2018, 4.29 pm
Molecular therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing   3,3′-Diindolylmethane (DIM) Sodium nitrite(NaNO2), and  Sodium Sulfide (DIMSNSS) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 20/May/2018, 4.29 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory of Molecular Target and…

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A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose),isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene, 20/May/2018, 3.36 pm
A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose),isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene, 20/May/2018, 3.36 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose), isolated from agavi,…

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A glycolipid-based therapy for glucose homeostasis and TIIDM: α-Galactosylceramide (α-gal-cer), a synthetic glycolipid, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 18/May/2018, 2.03 pm
A glycolipid-based therapy for glucose homeostasis and TIIDM: α-Galactosylceramide (α-gal-cer), a synthetic glycolipid, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 18/May/2018, 2.03 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Glycolipid-based Lifespan extension therapy:  α-galactosylceramide (α-GalCer), a synthetic glycolipid, increases life span via up-regulation of its target gene BubR1, 18/May/2018, 1.29 pm
Glycolipid-based Lifespan extension therapy:  α-galactosylceramide (α-GalCer), a synthetic glycolipid, increases life span via up-regulation of its target gene BubR1, 18/May/2018, 1.29 pm 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Amylin comes to the rescue of autoimmune diabetes: Amylin-based adjunct therapy for autoimmune diabetes (TIDM): Amylin, a 37-residue peptide hormone, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 18/May/2018, 11.29 am
Amylin comes to the rescue of autoimmune diabetes: Amylin-based adjunct therapy for autoimmune diabetes (TIDM): Amylin, a 37-residue peptide hormone, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 18/May/2018, 11.29 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of Milan, Milan…

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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Hydrogen-rich saline increases the expression of tumor suppressors genes, such as  p53, TA-p73 and TA-p63, RECK and CADM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/May/2017, 10.45 am
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Hydrogen-rich saline increases the expression of tumor suppressors genes, such as  p53, TA-p73 and TA-p63, RECK and CADM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/May/2017, 10.45 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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