Ideas

November 1, 2018

Published by admin_auro at November 1, 2018

Categories

Cancer
Ideas

Probiotic-based therapy for cancer: Probiotic Lactobacillus rhamnosus inhibits the expression of mTORC1 and its downstream target AMD1, dismantles mTORC1-AMD1 signaling network, decreases polyamine levels, and inhibits prostate cancer progression via upregulation of its target gene, 1/November/2018, 11.39 pm

Introduction: What they say: A study from CIC bioGUNE (Center for Cooperative Research in Biosciences), Bizkaia Technology Park, 801 Building, 48160 Derio, Spain shows that “mTORC1-dependent AMD1 regulation sustains polyamine […]

November 1, 2018

Published by admin_auro at November 1, 2018

Categories

Cancer
Ideas

Probiotic-based therapy targeting cancer stem cells in Myeloid leukaemia (ML): Probiotic Lactobacillus rhamnosus inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 11/November/2018, 11.13 pm

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem […]

November 1, 2018

Published by admin_auro at November 1, 2018

Categories

Ideas
Stroke

Repurposing the anti-hypertensive agent into a stroke medicine: Aliskiren (Tekturna and Rasilez), a renin inhibitor used in the treatment of hypertension, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 1/November/2018, 4.50 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]

November 1, 2018

Published by admin_auro at November 1, 2018

Categories

Act(os) against cancer: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as KIBRA, GAS5, p53, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene,1/November/2018, 4.40 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]