Ideas

November 1, 2018

Published by admin_auro at November 1, 2018

Categories

Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Valsartan (trade name: Diovan), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 1/November/2018, 3.18 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]

October 31, 2018

Published by admin_auro at October 31, 2018

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Probiotics as Exercise mimetics: A probiotic-based exercise mimetic therapy for Metabolic disease: Probiotic Clostridium butyricum CGMCC0313.1 increases PPARδ and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise, via down-regulation of its target gene, 31/October/2018, 10.24 pm

Introduction: What they say A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows […]

October 30, 2018

Published by admin_auro at October 30, 2018

Categories

Cancer
Ideas

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Act1 (Adaptor for IL-17 receptors) increases the expression of tumor suppressors genes, such as PDCD4, CADM1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 30/October/2018, 11.01 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

October 30, 2018

Published by admin_auro at October 30, 2018

Categories

Cancer
Ideas

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as PTPN14, RB1, p53, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 30/October/2018, 10.53 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]