Ideas

October 26, 2018

Published by admin_auro at October 26, 2018

Categories

Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Ambrisentan(trade name: Letairis, Volibris, Pulmonext), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 26/October/2018, 11.28 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]

October 26, 2018

Published by admin_auro at October 26, 2018

Categories

Cancer
Ideas

Awakening the sleeping/cancer-protecting angels in mutant p53 human tumors: Sulindac (brand name: Clinoril), a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of acute and chronic inflammatory conditions, increases the expression of tumor suppressors genes, such as CCM3/KRIT1, TPM1, p53, TAp63, TAp73, INK4a, and others, and induces regression of p53-mutated human cancers and other cancers, via up-regulation of its target gene, 26/October/2018, 11.14 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

October 26, 2018

Published by admin_auro at October 26, 2018

Categories

Lengthening the lifespan of mighty humans with tiny probiotics: Probiotic Lactobacillus Salivarius LA307-based lifespan extension therapy: Lactobacillus Salivarius LA307 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes, 26/September/2018, 7.34 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]

October 26, 2018

Published by admin_auro at October 26, 2018

Categories

Dealing harmful infective agents with Probiotics (good bacteria): Probiotics-based adjuvant therapy for viral and bacterial infections: Probiotic Lactobacillus crispatus inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene, 26/October/2018, 7.19 am

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]