Ideas

Molecular therapy for glaucoma: Valproic acid (brand name: Convulex and others), used in the treatment of epilepsy, bipolar disorder, migraine headaches and others,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 20/April/2018,  12.21 pm
Molecular therapy for glaucoma: Valproic acid (brand name: Convulex and others), used in the treatment of epilepsy, bipolar disorder, migraine headaches and others,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 20/April/2018,  12.21 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes…

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A sweetest way to say no to blood sugar disease: Natural sweetener-based therapy for TIIDM: Phyllodulcin, a natural sweetener 400-800 times sweeter than sugar,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 20/April/2018, 11.11 am
A sweetest way to say no to blood sugar disease: Natural sweetener-based therapy for TIIDM: Phyllodulcin, a natural sweetener 400-800 times sweeter than sugar,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 20/April/2018, 11.11 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Amitriptyline (trade name: Elavil), a medication used to treat major depressive disorder, anxiety disorder, and bipolar disorder, increases the expression of tumor suppressors genes, such as TA-p73/p63, TPM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/April/2017, 11.41 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Amitriptyline (trade name: Elavil), a medication used to treat major depressive disorder, anxiety disorder, and bipolar disorder, increases the expression of tumor suppressors genes, such as TA-p73/p63, TPM1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/April/2017, 11.41 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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An essential oil-based therapy for Deafness: A therapeutic mix encompassing  Rosa mosqueta oil, Cholecalciferol, Ajoene and DIM (RMCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 18/April/2018, 11.25 pm
An essential oil-based therapy for Deafness: A therapeutic mix encompassing  Rosa mosqueta oil, Cholecalciferol, Ajoene and DIM (RMCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 18/April/2018, 11.25 pm 960 720 Dr Boomi's Genom-2-Discovery Center

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: An essential  oil-based therapy for Deafness: A therapeutic mix encompassing  Rosa mosqueta oil, Cholecalciferol, Ajoene and DIM (RMCAD) increases the expression…

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Androsterone-based therapy for blood sugar disease (autoimmune diabetes (TIDM)):  Dehydroepiandrosterone (DHEA) and its metabolite HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol)  increase PD-L1 expression,  augment Tregs function, promote immune tolerance, increase pancreatic β-cell proliferation and regeneration, increase insulin secretion, improve insulin sensitivity, increase energy utilization, and reverse TIDM, via up regulation of its target gene, 18/April/2018,  10.40 pm
Androsterone-based therapy for blood sugar disease (autoimmune diabetes (TIDM)):  Dehydroepiandrosterone (DHEA) and its metabolite HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol)  increase PD-L1 expression,  augment Tregs function, promote immune tolerance, increase pancreatic β-cell proliferation and regeneration, increase insulin secretion, improve insulin sensitivity, increase energy utilization, and reverse TIDM, via up regulation of its target gene, 18/April/2018,  10.40 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of…

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Bonding your way to keep cardiac diseases at bay: Oxytocin-based intranasal inhalation therapy for cardiac rejuvenation: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 18/April/2018, 10.17 pm
Bonding your way to keep cardiac diseases at bay: Oxytocin-based intranasal inhalation therapy for cardiac rejuvenation: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 18/April/2018, 10.17 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A noble way to keep cardiac diseases at bay: Noble gas xenon-based cardiac rejuvenation therapy: Inhalation of…

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