Ideas

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as PTEN, PDCD4, INK4a, BTG2, TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/April/2017, 9.55 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as PTEN, PDCD4, INK4a, BTG2, TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 18/April/2017, 9.55 pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Treating blood sugar disease with antidepressants: Duloxetine-based therapy for diabetes (TIIDM): Duloxetine (Brand name: Cymbalta), used in the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and others, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 18/April/2018, 9.49 pm
Treating blood sugar disease with antidepressants: Duloxetine-based therapy for diabetes (TIIDM): Duloxetine (Brand name: Cymbalta), used in the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and others, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 18/April/2018, 9.49 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL shows that…

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Bonding your way to regenerate the lost cardiomyocytes in Myocardial patients: Oxytocin-based intranasal inhalation therapy for cardiac diseases: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on,  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 17/April/2018, 2.21 pm
Bonding your way to regenerate the lost cardiomyocytes in Myocardial patients: Oxytocin-based intranasal inhalation therapy for cardiac diseases: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on,  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 17/April/2018, 2.21 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April…

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Neurotensin-based therapy for body weight control, energy homeostasis and TIIDM: Neurotensin, a 13-amino acid neuropeptide known to play a role in thermoregulation and neuroprotection, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 17/April/2017, 2.09 pm
Neurotensin-based therapy for body weight control, energy homeostasis and TIIDM: Neurotensin, a 13-amino acid neuropeptide known to play a role in thermoregulation and neuroprotection, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 17/April/2017, 2.09 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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Stalling arthritic pain with antidepressants: Antidepressant-based therapy for inflammation and arthritis:Amitriptyline (brand name: Elavil), an antidepressant, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 17/April/2018, 1.58 pm
Stalling arthritic pain with antidepressants: Antidepressant-based therapy for inflammation and arthritis:Amitriptyline (brand name: Elavil), an antidepressant, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 17/April/2018, 1.58 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by…

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Bonding your way to say no to Cardiomyopathy: Oxytocin-based intranasal inhalation therapy for Cardiomyopathy: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on , decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via up regulation of its target gene, 17/April/2018, 1.48 pm
Bonding your way to say no to Cardiomyopathy: Oxytocin-based intranasal inhalation therapy for Cardiomyopathy: Oxytocin, a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on , decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy, via up regulation of its target gene, 17/April/2018, 1.48 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This…

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