Ideas

An omega-3 way to say no to Cardiomyopathy: PUFA-based therapy for Cardiomyopathy: ω-PUFAs (Docosahexaenoic acid (DHA) + Eicosapentaenoic acid (EPA)) decrease the expression of Sox6, restore the balance between slow- and fast-twitch myofiber proteins and alleviate Cardiomyopathy via up regulation of its target gene, 13/April/2018, 10.05 pm
An omega-3 way to say no to Cardiomyopathy: PUFA-based therapy for Cardiomyopathy: ω-PUFAs (Docosahexaenoic acid (DHA) + Eicosapentaenoic acid (EPA)) decrease the expression of Sox6, restore the balance between slow- and fast-twitch myofiber proteins and alleviate Cardiomyopathy via up regulation of its target gene, 13/April/2018, 10.05 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This…

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Natural product-derived therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing Baicalein, Salidroside and Carnosic acid (BCSSCA)  decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 13/April/2018, 9.23 am
Natural product-derived therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing Baicalein, Salidroside and Carnosic acid (BCSSCA)  decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 13/April/2018, 9.23 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory of Molecular Target and…

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Molecular therapy for Metastatic cancers: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/April/2017, 8.39 am
Molecular therapy for Metastatic cancers: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/April/2017, 8.39 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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Bonding your way to decrease blood pressure/sugar and extend lifespan: Oxytocin-based Lifespan and healthspan extension therapy: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 13/April/2018, 7.09 am
Bonding your way to decrease blood pressure/sugar and extend lifespan: Oxytocin-based Lifespan and healthspan extension therapy: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 13/April/2018, 7.09 am 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1)…

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 Life-extension therapy: Fenofibrate, a lipid-lowering medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/April/2017, 12.09 am
 Life-extension therapy: Fenofibrate, a lipid-lowering medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/April/2017, 12.09 am 960 720 Dr Boomi's Genom-2-Discovery Center

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Neuropeptide-based therapy for blood sugar disease (autoimmune diabetes (TIDM)):  Neuropeptide (NPY), a 36 amino-acid neuropeptide known to play a role in food intake and weight determination,  increases PD-L1 expression,  augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 12/April/2018,  11.50 pm
Neuropeptide-based therapy for blood sugar disease (autoimmune diabetes (TIDM)):  Neuropeptide (NPY), a 36 amino-acid neuropeptide known to play a role in food intake and weight determination,  increases PD-L1 expression,  augments Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 12/April/2018,  11.50 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of…

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