Ideas

October 10, 2018
Published by admin_auro at October 10, 2018
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Repurposing the analgesic agent Parecoxib into an anti-HIV agent: Parecoxib (trade name: Dynastat), a selective cox-2 (Cyclooxygease-2) inhibitor, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 11/october/2018, 12.14 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the analgesic agent Parecoxib into an anti-HIV agent: Parecoxib (trade name: Dynastat), a […]
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October 10, 2018
Published by admin_auro at October 10, 2018
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Probiotic-based therapy for tuberculosis: Probiotic Lactobacillus gasseri SBT2055 deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 11/October/2018, 12.01 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
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October 9, 2018
Published by admin_auro at October 9, 2018
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The PD1-PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Temozolomide, Mevastatin, Cyclabezaprine, Hydralizine, SNX5422, Salinomycin (TMCHSS) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signaling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 9/October/2018, 12.16 pm

Introduction:What they say: A recent study from Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California, USA; Jonsson Comprehensive Cancer […]
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October 9, 2018
Published by admin_auro at October 9, 2018
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Mechanistic insights into how Antiarrhythmic/Local anesthetic agent Pilsicainide may deteriorate memory, learning, and cognition: Pilsicainide (trade name: Sunrythm) decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 9/October/2018, 11.56 am

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
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