Cotton-derived compound may function as an antimalarial agent in controlling blood-stage Plasmodium infection: Gossypol, a natural compound derived from Cotton, decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria, via up regulation of its target gene, 3/April/2018, 10.36 pm
Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that “Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.” This research paper was published, in September 2017 issue of the journal “Nature Medicine” [One of […]
Treating blood sugar disease with dietary fibres: Inulin, a polysaccharide isolated from chicory, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 3/April/2018, 10.24 pm
Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL shows that “miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.” This research paper was published, in the 3 November 2017 issue of the journal “Diabetes” […]
Cotton-derived compound functions as an anti-HIV agent: Gossypol, a natural compound isolated from cotton, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 3/April/2017, 10.08 pm
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Cotton-derived compound functions as an anti-HIV agent: Gossypol, a natural compound isolated from cotton, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene [easy_payment currency=”USD”] From […]
A sweet way to say no to Diabetes Mellitus: Raffinose, a trisaccharide composed of galactose, glucose and fructose, augments the expression of FGF19 and FGF1, attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via up regulation of its target gene, 2/April/2018, 12.39 pm
Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained remission of diabetic hyperglycemia in rodents. This research paper was published, in the 23 May 2016 issue of the journal “Nature Medicine” [One of the […]
Treating pain with sweet: Sugar-based activation of the PD-1 pathway for Pain therapy: D-Mannose, a C-2 epimer of glucose commonly used in the treatment of urinary tract infections, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 2/April/2018, 12.31 pm
Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US, shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]
A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: D-Allose, a C-3 epimer of glucose, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 4/April/2018, 12.19 pm
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that D-Allose, by increasing the expression […]