Ideas

October 8, 2018

Published by admin_auro at October 8, 2018

Categories

Probiotics as learning/memory/cognitive-enhancer: Probiotic lactobacillus gasseri increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down regulation of its target genes, 8/October/2018, 11.30 pm

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA; Paul F. Glenn Center […]

October 8, 2018

Published by admin_auro at October 8, 2018

Categories

Mechanistic insights into how anesthetic agent Lidocaine may deteriorate memory, learning, and cognition: Lidocaine (trade name: xylocaine and lignocaine), a local anesthetic agent, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 8/October/2018, 7.32 pm

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA; Paul F. Glenn Center […]

October 8, 2018

Published by admin_auro at October 8, 2018

Categories

Ideas
Pain

Induction of the PD-1 pathway for Pain therapy: Nicotine, one of the components of cigarette smoke, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 8/October/2018, 6.20 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

October 5, 2018

Published by admin_auro at October 5, 2018

Categories

Cancer
Ideas

Activating tumor suppressor gene network for cancer therapeutics: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as RhoB, p57Kip2, p53, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 5/October/2018, 11.36 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]