Lifespan extension therapy: Hydrogen sulfide (H2S), a naturally produced gasotransmitter, may increase life span, via up-regulation of its target gene BubR1, 22/March/2018, 1.21 am
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the […]
Sugar-based anti-ageing and Lifespan extension therapy: Rebaudioside A, a natural sweetener, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 24/March/2018, 1.10 am
Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str. Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in […]
Sugar-based therapy for diabetes (TIIDM): D-Fagomine, an iminosugar isolated from mulberry leaves, among others, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/March/2018, 12.55 am
Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL shows that “miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.” This research paper was published, in the 3 November 2017 issue of the journal “Diabetes” […]
A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: Lactulose (brand name: Cholac, Generlac, Consulose, Duphalac) , a non-absorbable sugar that aids in the treatment of constipation and hepatic encephalopathy, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 24/March/2018, 12.41 am
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Lactulose, by increasing the expression of […]
Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Melatonin promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 24/March/2018, 12.32 am
Significance of the study: Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD; and (4) the global economic cost […]
A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener found in drugs, confections, toothpaste, and chewing gum, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 23/March/2018, 12.25 am
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Xylitol, by increasing the expression of […]
