Natural product-based Anti-ageing and Life extension therapy:  A pharmaceutical mixture encompassing Cepharanthine, Edaravone, Eugenol (bis), Isoliquiritigenin, Taxifolin (CEEIT) increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 08/October/2017, 7.17 am

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in […]

Lifespan extension therapy: Nateglinide, an anti- hyperglycemic medication,   increases life span via up-regulation of its target gene BubR1, 8/October/2016, 7.01 am

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the […]

 Life-extension therapy: Justicidin A, found in Justica Procumbens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 8/October/2017, 6.35am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others. What we […]

Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing  Deprenyl, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (DCCMUDIL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 7/October/2017, 12.01 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others. Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel […]

Natural product-based therapy for TIIDM: A pharmaceutical mixture encompassing Luteolin, Apogenin, Formononetin, Isoliquiritigenin , and Gallic acid (LAFIG) augments the expression of FGF19 and FGF1,   attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIIDM via up regulation of its target gene, 6/October/2017, 11.51 pm

Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained remission of diabetic hyperglycemia in rodents. This research paper was published, in the 23 May 2016 issue of the journal “Nature Medicine” [One of the […]

Natural product-derived therapy for anxiety and depression:  Gastrodin, found in Gastrodia elata Blume (GE), among others,  decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 6/October/2017, 11.41 pm

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA; and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA shows that “Phf8 loss […]