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Ideas

September 16, 2017

Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Oleic acid, isolated from Olive oil, sunflower oil and among others, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 16/September/2017, 11.20 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; […]
September 16, 2017

Natural product-derived exercise mementics therapy for Metabolic disease: β-Cryptoxanthin, isolated from Sweet peppers and Papaya, increases PPARδ  and Foxo1 levels, inhibits glucose catabolism, preserves glucose levels, stimulates FA catabolism, delays the onset of hypoglycemia and boosts endurance exercise via down regulation of its target gene, 16/September/2017, 6.58 am

Introduction: What they say A study from Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA shows […]
September 16, 2017

Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing MC44, Ganetesbib, Fluvastatin, 9cRA, PEITC, Withaferin A and Temozolomide (TMZ) (MGFRPWT) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 16/September/2017, 06.49 am

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]
September 16, 2017

Natural product-derived antiviral therapy against Hepatitis-B virus: Luteolin, found abundantly in Salvia tomentosa, increases the expression of Setd2, methylates STAT1, activates STAT1, promotes trimethylation of IFN-stimulated gene-15, and restricts Hepatitis-B virus (HBV) production and pathogenesis via up regulation of its target gene, 16/September/2017,  6.34 am

Introduction: What they say A study from the Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China; and Institute of Immunology, Zhejiang University School […]
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