Ideas

March 4, 2018

Published by admin_auro at March 4, 2018

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Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]

March 4, 2018

Published by admin_auro at March 4, 2018

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Amino acid-based therapy for TIIDM and obesity-associated metabolic deficits: Glycine, a non-essential amino acid and inhibitory neurotransmitter, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 4/March/2018, 11.45 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]

March 4, 2018

Published by admin_auro at March 4, 2018

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Non-absorbable sugar based Lifespan extension therapy: Lactulose (brand names: Cholac, Generlac, Consulose, Duphalac, others), a non-absorbable sugar aids in the treatment of constipation and hepatic encephalopathy, increases life span via up-regulation of its target gene BubR1, 4/March/2018, 11.27 am

What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]

March 4, 2018

Published by admin_auro at March 4, 2018

Categories

Ideas
Pain

Activation of the PD-1 pathway for Pain therapy: DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin), a synthetic opioid peptide, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 4/March/2017, 11.07 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]