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Ideas

September 13, 2017

Natural product therapy for pulmonary arterial hypertension: Punicalagin (PG), isolated from Punica granatum,  inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 13/September/2017, 9.58 am

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
September 13, 2017

Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Ursodeoxycholic acid (UDCA) [Trade name: Actigall, Udcasid] promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 12/September/2017, 9.49 am

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; […]
September 13, 2017

Molecular therapy for Metastatic cancers: Ivermectin, the anthelmintic drug, increases the expression of metastasis/tumor suppressors  Big-H3 and TIPE2, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/September/2017, 9.44 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
September 12, 2017

Natural product-based therapy for TIIDM: A pharmaceutical mixture encompassing Celastrol, Mangiferin, Fisetin, Spermidine, and Ursolic acid (CMFSU) augments the expression of FGF19 and FGF1,   attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIIDM via up regulation of its target gene, 13/September/2017, 12.13 am

Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
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