Ideas

March 2, 2018

Published by admin_auro at March 2, 2018

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Small-molecule based therapy for autoimmune diabetes (TIDM): Sarcocine (N-Methyl Glycine) , a derivative of amino acid glycine, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 2/March/2018, 7.33 am

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and […]

March 2, 2018

Published by admin_auro at March 2, 2018

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Molecular therapy for body weight control, energy homeostasis and TIIDM: Spermidine, an endogenous polyamine, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 2/March/2018, 7.17 am

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]

March 1, 2018

Published by admin_auro at March 1, 2018

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Ideas
Pain

Activation of the PD-1 pathway for Pain therapy: DADLE ([D-Ala2, D-Leu5]-Enkephalin), a synthetic opioid peptide, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 1/March/2017, 10.56 pm

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

February 28, 2018

Published by admin_auro at February 28, 2018

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Combinatorial therapy for Deafness: A therapeutic mix encompassing Spermidine, Cholecalciferol, Ajoene and DIM (SCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 28/February/2018, 11.55 pm

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma ideas posted […]