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Ideas

September 6, 2017

 Molecular therapy for muscle atrophy and wasting:Ruxolitinib (Trade name: Jakavi/Jakafi), a drug used in the treatment of Myelofibrosis, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 6/September/2017, 11.57 pm

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France […]
September 6, 2017

Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of context-dependent tumor suppressors  Sox2 and IL1-β, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 6/September/2017, 11.42 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
September 5, 2017

The PD-1 pathway activation for Pain therapy: Rivaroxaban, an anti-coagulant and a blood thinner,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 6/september/2017, 12.28 am

Teacher’s day special ********* We wish everyone a happy Teacher’s day. On this special occasion, we are happy to announce that ideas posted today (05/September/2017) will be available to […]
September 5, 2017

Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Linalool, isolated from Lavender, among others,  increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 6/September/2017, 12.09 am

Teacher’s day special ********* We wish everyone a happy Teacher’s day. On this special occasion, we are happy to announce that ideas posted today (05/September/2017) will be available to […]
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