Ideas

Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Dihydroartemisinin (DHA), isolated from Artemesia Annua L,  decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 26/August/2017, 12.56 pm
Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Dihydroartemisinin (DHA), isolated from Artemesia Annua L,  decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 26/August/2017, 12.56 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; and Broad Institute of…

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Natural product-derived therapy for tuberculosis: β-Cryptoxanthin, isolated from Paprika, Buah Merah, Papaya,  Satsuma Mandarin and among others, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 25/August/2017, 11.59 pm
Natural product-derived therapy for tuberculosis: β-Cryptoxanthin, isolated from Paprika, Buah Merah, Papaya,  Satsuma Mandarin and among others, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 25/August/2017, 11.59 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows…

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Natural product-derived antiviral therapy for HIV virus: Ivermectin (Brand name: Heartguard/Mectizen/Stromectol)  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 25/August/2017, 11.46 pm
Natural product-derived antiviral therapy for HIV virus: Ivermectin (Brand name: Heartguard/Mectizen/Stromectol)  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 25/August/2017, 11.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, New York, NY 10032,…

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Natural product-derived therapy for heart regeneration and repair: β-Cryptoxanthin, isolated from Satsuma Mandarin, Buah Merah, Papaya, Paparika and among others, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 25/August/2017, 7.53 am
Natural product-derived therapy for heart regeneration and repair: β-Cryptoxanthin, isolated from Satsuma Mandarin, Buah Merah, Papaya, Paparika and among others, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 25/August/2017, 7.53 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708,…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A therapeutic mix encompassing Berberine, Gambogic acid, β-Cryptoxanthin (BCX) [BGBCX]  increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via up regulation of its target gene, 25/August/2017, 5.20 am
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A therapeutic mix encompassing Berberine, Gambogic acid, β-Cryptoxanthin (BCX) [BGBCX]  increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via up regulation of its target gene, 25/August/2017, 5.20 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of tumor suppressors PDCD4 and PTEN, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 25/August/2017, 4.48 am
Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of tumor suppressors PDCD4 and PTEN, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 25/August/2017, 4.48 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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