Natural product-derived therapy for muscle atrophy and wasting:Mangiferin, isolated from Mangoes (Mangefera Indica), increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 12/August/2017, 11.18 pm

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France shows that FGF19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. This research paper was published, in the 26 June 2017 issue of the journal “Nature Medicine” [One of the best […]

Natural product-derived Combination therapy for Squamous cell carcinoma of head and neck (HNSCC): A therapeutic mix encompassing Ivermectin and 1,25-dihydroxyvitamin D/Cholecalciferol may decrease BMI1 and AP-1 expression, overcome chemotherapeutic resistance, promote chemosensitivity, suppress cancer stem cells in HNSCC, and inhibit lymph node metastasis via down regulation of its target genes, 12/August/2017,  10.43 pm

Introduction: What they say: A study from the Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, California, USA shows that inhibition of BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. This study was published, in the 9 […]

Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Sulphoraphane, Diindolylmethane (3,3′-DIM, DIM) and Vitamin-D dissolved in Hydrogen-rich water activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 12/August/2017, 12.14 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others. Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel […]

Natural product-derived therapy for tuberculosis:  Dihydroartimisin, isolated from Artemesia Annua L, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 12/August/2017, 12.05 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows that “Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.” This study was published in the 24 March 2017 issue of […]

Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: β-caryophyllene, isolated from black pepper among others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 11/August/2017, 11.56 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761), by Prof Tzahor E, D’Uva G, and others. What we say:  […]

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Ivermectin, the anti-parasitic drug, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 11/August/2017, 11.41 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This study was published in the 3 January 2017 issue of the journal “Journal of Clinical Investigations” [one of the best journals General medicine with an I.F of 12.5+] by Prof. Amato J. Giaccia, […]