Ideas

Natural product-derived therapy for gynecologic cancers: Artemisinin, one of the main components  of herb Artemesia Annna L, inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 9/August/2017, 11/54 pm
Natural product-derived therapy for gynecologic cancers: Artemisinin, one of the main components  of herb Artemesia Annna L, inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 9/August/2017, 11/54 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on HDAC6 activity” This study…

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 Antiviral therapy for HIV virus: Auranofin, a drug used in the treatment of Rheumatoid arthritis,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 9/August/2017, 11.46 pm
 Antiviral therapy for HIV virus: Auranofin, a drug used in the treatment of Rheumatoid arthritis,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 9/August/2017, 11.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Antiviral therapy for HIV virus: Auranofin, a drug used in the treatment of Rheumatoid arthritis,  increases Heme oxygenase 2…

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Natural product-derived Lifespan extension therapy: Mangiferin, isolated from Mangoes,  prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 9/August/2017, 11.37 pm
Natural product-derived Lifespan extension therapy: Mangiferin, isolated from Mangoes,  prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 9/August/2017, 11.37 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1)…

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Life-extension therapy: Auranofin, a drug used in the treatment of  Rheumatoid arthritis,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 9/August/2017, 11.29 pm
Life-extension therapy: Auranofin, a drug used in the treatment of  Rheumatoid arthritis,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 9/August/2017, 11.29 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Natural product-based therapy for anxiety and depression:  Magnolol, isolated from Houpu Magnolia and Magnolia Grandiflora (MG),  decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 9/August/2017, 12.54 am
Natural product-based therapy for anxiety and depression:  Magnolol, isolated from Houpu Magnolia and Magnolia Grandiflora (MG),  decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression via down regulation of its target gene, 9/August/2017, 12.54 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department of Stem Cell and…

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Natural product-based Anti-ageing and Life extension therapy: Dihydroartemisinin, isolated from Artemisia Annua,  increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 9/August/2017, 12.53  am
Natural product-based Anti-ageing and Life extension therapy: Dihydroartemisinin, isolated from Artemisia Annua,  increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 9/August/2017, 12.53  am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann…

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