Natural product-based therapy for Cardiomyopathy: Kaemphferol, isolated from Aloe vera, and apples and among others, decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 18/July/2017, 1.08 am

Introduction: What they say A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This study was published, in the 2 June  2015 issue of the journal “Nature Genetics” (the number 1 research journal in Genetics with an impact factor of 29.648), by Prof. Da-Zhi Wang & Jian Ding, and […]

Natural product-derived regenerative therapy for muscular atrophy: Idesolide, isolated from Idesia Polycarpa, increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 18/July/2017, 12.21 am

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of muscle atrophy.” This research paper was published, in the 25 May 2017 issue of the journal “Nature communications” [One of the best research journals in Biology with an I.F of 11.329 ], by Prof. […]

Natural product-based Combinatorial therapy for TIIDM and Metabolic disease: A therapeutic mix encompassing Cholecalciferol, Oleanolic acid and Magnolol decreases blood glucose levels, stifles Hemoglobin A1c and fructosamine levels, brings down the levels of inflammatory mediators, augments insulin sensitivity, increases energy expenditure, promotes weight loss and alleviates TIIDM, metabolic disease and hepatic steatosis via up regulation of its target gene, 17/July/2017, 11.59 pm

Introduction: What they say A study from Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Medicine and Pharmacology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA; Division of Metabolism, Endocrinology, and Diabetes, Department of Medicine, and Brehm Center for Diabetes, University of Michigan Medical School, […]

Natural product therapy for glucose homeostasis and TIIDM: β-Cryptoxanthin, isolated from Sweet peppers and Papaya, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 17/July/2017, 12.23 am

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published, in the 12 December 2016 issue of the journal “Journal of Clinical investigations” [One […]

Molecular therapy for Diabetic nephropathy (DN): Argonaute2 (Ago2) increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 17/July/2017, 12.18 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.” This research paper was published, in the 24 April 2017 issue of the journal “Nature Medicine” [One of the best research journals in “Molecular […]

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: KChip2 increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene, 17/July/2017, 12.13 am

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71]  by Prof and Dean of the Harvard […]