Ideas

Anti-telomerase cancer therapy: RBM24 (RNA Binding Motif Protein 24) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 6/July/2017, 11.01 pm
Anti-telomerase cancer therapy: RBM24 (RNA Binding Motif Protein 24) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 6/July/2017, 11.01 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product-derived therapy for muscle atrophy and wasting: Berberine, isolated from Berberis among others, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 6/July/2017, 10.26 pm
Natural product-derived therapy for muscle atrophy and wasting: Berberine, isolated from Berberis among others, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 6/July/2017, 10.26 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France shows that FGF19 regulates skeletal…

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Electro stimulation therapy for Myocardial Infarction: Electro stimulation therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up regulation of PNUTS, 6/July/2017, 10.13 pm
Electro stimulation therapy for Myocardial Infarction: Electro stimulation therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up regulation of PNUTS, 6/July/2017, 10.13 pm 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Low frequency magnetic field-based anti-metastatic therapy for CyclinD3-CDK6 overexpressing cancers: Low frequency magnetic field increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 6/July/2017, 7.21 am
Low frequency magnetic field-based anti-metastatic therapy for CyclinD3-CDK6 overexpressing cancers: Low frequency magnetic field increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 6/July/2017, 7.21 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA shows that “The metabolic function of…

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Anti-telomerase cancer therapy: CHOP/GADD153 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 6/July/2017, 7.14 am
Anti-telomerase cancer therapy: CHOP/GADD153 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 6/July/2017, 7.14 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

read more

Molecular therapy for brain tumor and oesophageal squamous cell carcinoma: Metformin, the widely used drug in the treatment of TIIDM, inhibit the expression of Integrin a7 (ITGA7), impair laminin-induced/FAK mediated signalling, inhibit the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppress tumor cell migration, reduce metastasis and prolong survival via down regulation of its target gene, 6/July/2017, 6.58 am
Molecular therapy for brain tumor and oesophageal squamous cell carcinoma: Metformin, the widely used drug in the treatment of TIIDM, inhibit the expression of Integrin a7 (ITGA7), impair laminin-induced/FAK mediated signalling, inhibit the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppress tumor cell migration, reduce metastasis and prolong survival via down regulation of its target gene, 6/July/2017, 6.58 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Institute of General Pathology, Università Cattolica del Sacro Cuore and Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy; Department of Oncology and Molecular Medicine – Istituto…

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