Ideas

Natural product-derived therapy for brain tumor and oesophageal squamous cell carcinoma: Cirsilol, a flavone isolated from Achillea fragrantissima, inhibits the expression of Integrin a7 (ITGA7), impairs laminin-induced/FAK mediated signalling, inhibits the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 20/June/2017, 10.46 pm
Natural product-derived therapy for brain tumor and oesophageal squamous cell carcinoma: Cirsilol, a flavone isolated from Achillea fragrantissima, inhibits the expression of Integrin a7 (ITGA7), impairs laminin-induced/FAK mediated signalling, inhibits the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 20/June/2017, 10.46 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Institute of General Pathology, Università Cattolica del Sacro Cuore and Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy; Department of Oncology and…

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The PD-1 pathway activation for Pain therapy: Pyruvate, the end product of glycolysis, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 20/June/2017, 10.51 am
The PD-1 pathway activation for Pain therapy: Pyruvate, the end product of glycolysis, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 20/June/2017, 10.51 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Low-intensity Electroporal shock wave-based regenerative therapy for muscular atrophy: Low-intensity Electroporal shock wave therapy increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 20/June/2017, 10.35 am
Low-intensity Electroporal shock wave-based regenerative therapy for muscular atrophy: Low-intensity Electroporal shock wave therapy increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 20/June/2017, 10.35 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of…

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Natural product-derived therapy for Acute Myeloid Leukemia: Theabrownin (TB), isolated from the fresh leaves of Camellia sinensis, decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 20/June/2017, 8.15 am
Natural product-derived therapy for Acute Myeloid Leukemia: Theabrownin (TB), isolated from the fresh leaves of Camellia sinensis, decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 20/June/2017, 8.15 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Institute of Genetics and Biophysics, CNR, Naples, Italy; and Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy…

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Epidermal growth factor therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: EGF (Epidermal growth factor) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene. 20/June/2017, 8.06 am
Epidermal growth factor therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: EGF (Epidermal growth factor) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene. 20/June/2017, 8.06 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

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Natural product therapy for CyclinD3-CDK6 overexpressing cancers: Rhamnetin, isolated from Cloves, increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 20/June/2017, 7.21 am
Natural product therapy for CyclinD3-CDK6 overexpressing cancers: Rhamnetin, isolated from Cloves, increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 20/June/2017, 7.21 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA shows that “The…

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