Natural product-derived therapy for prostate cancer bone metastasis: Myrtenol, found in Cardamom, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 11/June/2017, 12.05 am

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes Prostate Cancer Metastasis by Engaging Tumor-Stromal Cell Interactions.” This study was published in the 13 March 2017 issue of the journal “Cancer Cell” [One of […]

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Celastrol and Cirsiliol, found in Thunder god vine and achillea fragrantissima, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 10/June/2017, 11.57 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This study was published in the 3 January 2017 issue of the journal “Journal of Clinical Investigations” [one of the best journals General medicine with an […]

Natural product-derived regenerative therapy for muscular atrophy: Berberine increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 10/June/2017, 12.10 am

Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of muscle atrophy.” This research paper was published, in the 25 May 2017 issue of the journal “Nature communications” [One of the best research journals in […]

Natural product-derived therapy for Stroke: Atractylenolide III, isolated from Atractylodes ovata, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 9/June/2017, 11.59 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 […]

Natural product-based therapy for Metabolic diseases: Salidroside, isolated from Rhodiola Rosea, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 9/June/2017, 11.59 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published in the June 8, 2011 Nature [One of the best journals in Science with an I.F of  >43] by Prof. Stoffel M, Trajkovski M and […]

Molecular therapy for pulmonary arterial hypertension: USF1 (Upstream Transcription Factor 1) inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 9/June/2017, 11.58 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of […]