Molecular therapy for metastasis: Urocanic acid inhibits the expression of IL-6/8, decreases the expression of down stream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via up regulation of its target gene, 9/June/2017, 11.56 pm
Introduction: What they say: A study from Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA; Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University, Baltimore, Maryland 21218, USA; and Department of Oncology and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA shows that “Synergistic […]
Hydrogen-rich water therapy for Lifespan extension: Hydrogen-rich water therapy prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/June/2017, 11.59 pm
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Hydrogen-rich water therapy, by […]
Natural product-derived therapy for glucose homeostasis and TIIDM: Salidroside, isolated from Rhodiola Rosea, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 8/June/2017, 11.36 pm
Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014 issue of the Journal “Journal of Experimental Medicine (JEM)” that: “The microRNA-212/132 cluster regulates B cell development by targeting Sox4.” Subsequently, Prof. Rorsman’s research team, […]
Natural product therapy for KRAS/LKB1-mutant lung cancer: Rhamnetin, isolated from cloves, increases the levels of tumor suppressor proteins, inhibits the expression of urea cycle enzyme carbamoyl phosphate synthetase-1 (CSP1), decreases pyrimidine pools, stalls DNA synthesis, and inhibits the progression of KRAS/LKB1-mutated lung cancers via up regulation of its target gene, 8/June/2017, 11. 34 pm
Introduction: What they say A study from the Children’s Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390, USA; Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas 75390, USA; and McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas 75390, USA shows that “CPS1 maintains pyrimidine pools and […]
Natural product therapy for glucose homeostasis and TIIDM: Astaxainthin, isolated from heaematococcus pluvialis, Pandalus, and Phaffia, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 8/June/2-17, 11.32 pm
Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published, in the 12 December 2016 issue of […]
Natural product-derived regenerative therapy for muscle atrophy: L-Leucine, an essential branched chain amino acid, increases the expression of IGF-1, PI3K(p85a) and B-Myb, decreases the expression of tumor suppressors, promotes regeneration of muscle cells, and reverses muscle atrophy via up regulation of its target gene, 8/June/2017, 11.30 pm
Introduction: What they say A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, China shows that “miR-29b contributes to multiple types of muscle atrophy.” This research paper was published, in the 25 May 2017 issue of the journal “Nature communications” [One of the best research journals in […]