Ideas

December 28, 2017

Published by admin_auro at December 28, 2017

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Natural product-derived therapy for muscle atrophy and wasting:Acacetin, isolated from Robinia pseudoacacia (black locust) and anoda cristata, among others, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 29/December/2017, 12.24 am

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard […]

December 28, 2017

Published by admin_auro at December 28, 2017

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Combinatorial Antiviral Therapy (CAT): Amodiaquine (ADQ), an antifungal drug, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytical , Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 29/December/2017, 12.16 am

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA […]

December 28, 2017

Published by admin_auro at December 28, 2017

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Ideas
Pain

Activation of the PD-1 pathway for Pain therapy: Diclofenac, a drug used in the treatment of osteoarthritis and migraine, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 29/December/2017, 12.10 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

December 28, 2017

Published by admin_auro at December 28, 2017

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Molecular therapy for TIIDM and Metabolic defects: A pharmaceutical mixture (PMEA) encompassing Pyridoxamin (PM) and Etacrynic acid (EA) increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 29/December/2017, 12.03 am

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]