Ideas

Natural product-derived therapy for Metastatic cancers: Dihydromyricetin (DHM), found in Ampeopsis Grossdentatam, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 12.04 am
Natural product-derived therapy for Metastatic cancers: Dihydromyricetin (DHM), found in Ampeopsis Grossdentatam, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 12.04 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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Natural product-derived therapy for Chronic Myeloid leukaemia (CML): Honokiol, isolated from Magnolia Grandiflora (MG), decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 29/May/2017, 11.43 pm
Natural product-derived therapy for Chronic Myeloid leukaemia (CML): Honokiol, isolated from Magnolia Grandiflora (MG), decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 29/May/2017, 11.43 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Biochemistry-Molecular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, Georgia 30602, USA; and The University of…

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Natural product-derived therapy therapy for Stroke: Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 29/May/2017, 10.40 pm
Natural product-derived therapy therapy for Stroke: Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 29/May/2017, 10.40 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public…

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Laminar shear stress-based therapy for Diabetic nephropathy (DN): Laminar flow-induced shear stress increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 29/May/2017, 12.24 am
Laminar shear stress-based therapy for Diabetic nephropathy (DN): Laminar flow-induced shear stress increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 29/May/2017, 12.24 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may protect against the progression…

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Natural product-based Anti-ageing and Life extension therapy: Celastrol, isolated from herb Thunder God Vine, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 29/May/2015, 12.14 am
Natural product-based Anti-ageing and Life extension therapy: Celastrol, isolated from herb Thunder God Vine, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 29/May/2015, 12.14 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann…

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Natural product-based therapy for Inflammatory bowel disease: Genistein, isolated from Soy products, decreases the expression of oncostatin M, attenuates activation of oncostatin M- oncostatin M receptor pathway in inflamed colon tissues, inhibits inflammatory gene expression, attenuates colonic pathogenesis, and inhibits the progression of inflammatory bowel disease and colitis via down regulation of its target gene, 28/May/2017, 11.53 am
Natural product-based therapy for Inflammatory bowel disease: Genistein, isolated from Soy products, decreases the expression of oncostatin M, attenuates activation of oncostatin M- oncostatin M receptor pathway in inflamed colon tissues, inhibits inflammatory gene expression, attenuates colonic pathogenesis, and inhibits the progression of inflammatory bowel disease and colitis via down regulation of its target gene, 28/May/2017, 11.53 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK shows…

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