Ideas

Vitamin-based anti-metastatic therapy for Notch1-overexpressing Human cancers: Δ-Tocotrienol, a form of Vitamin-E, inhibits the expression of Notch1, and adhesion molecule VCAM1, suppresses neutrophil infiltration and tumor cell adhesion to endothelium, and prevents Notch1-driven metastasis via up regulation of its target gene, 24/May/2017, 7.28 am
Vitamin-based anti-metastatic therapy for Notch1-overexpressing Human cancers: Δ-Tocotrienol, a form of Vitamin-E, inhibits the expression of Notch1, and adhesion molecule VCAM1, suppresses neutrophil infiltration and tumor cell adhesion to endothelium, and prevents Notch1-driven metastasis via up regulation of its target gene, 24/May/2017, 7.28 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Vascular Signaling and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Vascular Biology, CBTM, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim,…

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Mechanical Stretch therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Mechanical Stretch therapy increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28, 24/May/2017, 7.26 am
Mechanical Stretch therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Mechanical Stretch therapy increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28, 24/May/2017, 7.26 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates…

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Music-based PD-1 pathway blockade for Human cancer therapy: Music therapy decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/May/2017, 11.57 pm
Music-based PD-1 pathway blockade for Human cancer therapy: Music therapy decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/May/2017, 11.57 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Amino-acid based therapy for Glaucoma: L-Leucine, the branched chain amino acid, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma via down regulation of its target gene, 22/May/2017, 11. 55 pm
Amino-acid based therapy for Glaucoma: L-Leucine, the branched chain amino acid, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma via down regulation of its target gene, 22/May/2017, 11. 55 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes…

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Laminar shear stress-based therapy for pulmonary fibrosis: Laminar shear stress decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via up regulation of its target gene, 22/May/2017, 11.54 pm
Laminar shear stress-based therapy for pulmonary fibrosis: Laminar shear stress decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via up regulation of its target gene, 22/May/2017, 11.54 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Laminar shear stress-based therapy for pulmonary fibrosis: Laminar shear stress decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53…

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Amino-acid based therapy for Inflammatory bowel disease: Leucine, the branched chain amino acid, decreases the expression of oncostatin M, attenuates activation of oncostatin M- oncostatin M receptor pathway in inflamed colon tissues, inhibits inflammatory gene expression, attenuates colonic pathogenesis, and inhibits the progression of inflammatory bowel disease and colitis via down regulation of its target gene, 22/May/2017, 11.50 pm
Amino-acid based therapy for Inflammatory bowel disease: Leucine, the branched chain amino acid, decreases the expression of oncostatin M, attenuates activation of oncostatin M- oncostatin M receptor pathway in inflamed colon tissues, inhibits inflammatory gene expression, attenuates colonic pathogenesis, and inhibits the progression of inflammatory bowel disease and colitis via down regulation of its target gene, 22/May/2017, 11.50 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK shows…

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