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Ideas

June 20, 2017

Natural product-derived therapy for Acute Myeloid Leukemia: Theabrownin (TB), isolated from the fresh leaves of Camellia sinensis, decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 20/June/2017, 8.15 am

Introduction: What they say: A study from the Institute of Genetics and Biophysics, CNR, Naples, Italy; and Department of Biochemistry, Biophysics and General Pathology, Second University […]
June 20, 2017

Epidermal growth factor therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: EGF (Epidermal growth factor) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene. 20/June/2017, 8.06 am

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The […]
June 20, 2017

Natural product therapy for CyclinD3-CDK6 overexpressing cancers: Rhamnetin, isolated from Cloves, increases the levels of tumor suppressor proteins, inhibits the activity of glycolytic enzymes 6-phosphofructokinase and pyruvate kinase M2, decreases antioxidants NADPH and glutathione levels, increases reactive oxygen species levels, promotes apoptosis, and inhibits the progression of CyclinD3-CDK6 overexpressing cancers via down regulation of its target gene, 20/June/2017, 7.21 am

Introduction: What they say A study from Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; and Department of Genetics, Harvard Medical School, Boston, Massachusetts, […]
June 18, 2017

Natural product-derived therapy for brain tumor and oesophageal squamous cell carcinoma: Honokiol, one of the components of Magnolia grandiflora, inhibits the expression of Integrin a7 (ITGA7), impairs laminin-induced/FAK mediated signalling, inhibits the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 18/June/2017, 11.59 pm

Introduction: What they say: A study from the Institute of General Pathology, Università Cattolica del Sacro Cuore and Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy; […]
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