Ideas

October 15, 2017

Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Zinc metallochaperone-1 (ZMC1), Formononetin, Apigenin, EGCG, Chloroquine, Tubascin, Triptolide, Temozolomide, Cholecalciferol, Dehydroleucodine, PEITC, & Linalool  (ZMC1FAECTTTCDPL) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 16/October/2017, 12.33 am

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]
October 15, 2017

Vitamin/amino acid-based combinatorial therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix encompassing Vitamin-E, Taurine and Vitamin-C (VETAVC) increases REV-ERB and its down stream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 15/October/2017,11.54 pm

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
October 14, 2017

Antiviral therapy for HIV virus: Nimesulide, a drug used to relieve pain,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 15/October/2017, 1.14 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Antiviral therapy for HIV virus: Nimesulide, a drug used to relieve pain,  increases Heme […]
October 14, 2017

Antiviral therapy for Neuroinvasive West Nile virus: Rifampicin, an antibiotic used in the treatment of tuberculosis, leprosy, and Legionnaire’s disease, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 15/October/2017, 1.06 am

Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of […]
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