Ideas

November 29, 2017

Published by admin_auro at November 29, 2017

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Molecular therapy for Deafness: a therapeutic mix encompassing Aripiprazole, Cholecalciferol, Ajoene and DIM (ACAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via up regulation of its target genes, 29/November/2017, 11.40 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Deafness: a therapeutic mix encompassing Aripiprazole, Cholecalciferol, Ajoene and DIM (ACAD) increases the expression […]

November 29, 2017

Published by admin_auro at November 29, 2017

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Salinomycin, Amitriptyline, Temozolomide, Berberine, Rosuvastatin and 17-DMAG (SATBRD) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival, via up-regulation of its target gene, 29/November/2017, 10.29 pm

Introduction:What they say: A recent study from Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California, USA; Jonsson Comprehensive Cancer […]

November 29, 2017

Published by admin_auro at November 29, 2017

Categories

Ideas
Pain

Activation of the PD-1 pathway for Pain therapy: Ketamine increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 29/November/2017, 8.26 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]

November 29, 2017

Published by admin_auro at November 29, 2017

Categories

Amino acid-based therapy for ageing-associated diseases and Lifespan extension: Glycine increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 29/November/2017, 8.17 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]