Ideas

November 25, 2017
Published by admin_auro at November 25, 2017
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Natural product-based combination therapy targeting cancer stem cells in Myeloid leukaemia (ML): A therapeutic mix encompassing Pseudolaric acid B, Rosiglitazone, Ivermectin, Dacogen (PRID) inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 25/November/2017, 4.13 pm

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem […]
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November 25, 2017
Published by admin_auro at November 25, 2017
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Natural product therapy for body weight control, energy homeostasis and TIIDM:  Resveratrol, isolated from Polygonum Cuspidatum, grapes, ground nuts, among others,  decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 25/November/2017, 4.06 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]
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November 25, 2017
Published by admin_auro at November 25, 2017
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Natural product-derived therapy for Myocardial Infarction: Hypaphorine, isolated from Caragana korshinskii Kom, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via  up-regulation of PNUTS,  25/November/2017, 3.55 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of Nature,  by Prof Dimmler, […]
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November 25, 2017
Published by admin_auro at November 25, 2017
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Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Lysophosphatidic acid (LPA) promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 25/November/2017, 3.45 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
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