Vitamin-based antiviral therapy against Neuroinvasive West Nile virus: Delta-Tocotrienol, a form of Vitamin-E, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 14/April/2017, 12.00 am
Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA shows that “RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.” This research paper was published in the 30 March 2017 issue of the […]
Amino acid-based therapy for TIIDM and obesity-associated metabolic deficits: L-Leucine, an essential amino acid found abundantly in parmesan cheese, soy, and hemp seeds among others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 13/April/2017, 5.29 pm
Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by bone-derived lipocalin 2.” This research paper was published in the 8 March 2017 issue of the journal “Nature” [One of the best research journals […]
Natural product-derived therapy for glucose homeostasis and TIIDM: Lucidone, isolated from Lindera erythrocarpa, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 13/April/2017, 8.04 am
Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]
Natural product derived-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Naringin, found in Grape fruits, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28
Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F […]
Natural product-derived therapy for brain repair and Lifespan extension: Avicularin, a flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 13/April/2017, 7.09 pm
What they say: Introduction: A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 […]
Cardiac rejuvenation therapy: Spermidine suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 12/April/2017, 10.56 pm
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Cardiac rejuvenation therapy: Spermidine suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene From the Significance of the study to Public health relevance: Given that: (1) cardiovascular disease is the leading cause of death worldwide; […]