Ideas

Natural product-derived therapy for tuberculosis: Berberine, isolated from Berberis Vulgaris, and Hydrastis Canadensis among others, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 11/April/2017, 10.59 pm
Natural product-derived therapy for tuberculosis: Berberine, isolated from Berberis Vulgaris, and Hydrastis Canadensis among others, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 11/April/2017, 10.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows…

read more

Natural product derived-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Lucidone, found in Lindera Erythrocarpa, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target, 11/April/2017, 10.26 pm
Natural product derived-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Lucidone, found in Lindera Erythrocarpa, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target, 11/April/2017, 10.26 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

read more

Natural product-derived therapy for Metastatic cancers: γ-Bisabolene, found in Cardamom, Cubeb pepper and Oregano among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 11/April/2017, 6.36 am
Natural product-derived therapy for Metastatic cancers: γ-Bisabolene, found in Cardamom, Cubeb pepper and Oregano among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 11/April/2017, 6.36 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

read more

Natural product-derived therapy for prostate cancer bone metastasis: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 11/April/2017, 12.01 am
Natural product-derived therapy for prostate cancer bone metastasis: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 11/April/2017, 12.01 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes…

read more

Natural product-derived therapy for Human cancers: α-Lipoic acid, found in leafy green vegetables, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 10/April/2017, 11. 45 pm
Natural product-derived therapy for Human cancers: α-Lipoic acid, found in leafy green vegetables, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 10/April/2017, 11. 45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; MIT…

read more

Natural product-derived therapy for Allergic rhinitis:Dioscin, a natural steroid saponin, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 10/April/2017, 11.29 pm
Natural product-derived therapy for Allergic rhinitis:Dioscin, a natural steroid saponin, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 10/April/2017, 11.29 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Dioscin, a natural steroid saponin,  inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among…

read more
Start Typing