Ideas

Natural product-derived regenerative therapy for reversing diabetes: Berberine, found in Berberis, Oregon grape, Hydrastis canadensis, and Phellodendron amurense among others, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 10/April/2017, 11.18 pm
Natural product-derived regenerative therapy for reversing diabetes: Berberine, found in Berberis, Oregon grape, Hydrastis canadensis, and Phellodendron amurense among others, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 10/April/2017, 11.18 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute…

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Amino-acid based therapy for tuberculosis:L-Leucine, a branched-chain amino acid (BCAA), deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 10/April/2017, 10.45 pm
Amino-acid based therapy for tuberculosis:L-Leucine, a branched-chain amino acid (BCAA), deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 10/April/2017, 10.45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows…

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Natural product-derived therapy for glucose homeostasis and TIIDM: Mangiferin (MA), found in Mangoes and Iris Unguicularis among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 10/April/2017, 11.35 am
Natural product-derived therapy for glucose homeostasis and TIIDM: Mangiferin (MA), found in Mangoes and Iris Unguicularis among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 10/April/2017, 11.35 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Natural product-derived antiviral therapy for HIV virus: Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 10/April/2017, 12.01 am
Natural product-derived antiviral therapy for HIV virus: Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 10/April/2017, 12.01 am 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived antiviral therapy for HIV virus: Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2…

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Natural product-derived therapy for Allergic rhinitis: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 9/April/2017, 11.36 pm
Natural product-derived therapy for Allergic rhinitis: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 9/April/2017, 11.36 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda…

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Natural product-derived therapy for Metastatic cancers: Shikonin, found in Zicao, among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 9/April/2017, 11.20 pm
Natural product-derived therapy for Metastatic cancers: Shikonin, found in Zicao, among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 9/April/2017, 11.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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