Ideas

Natural product-derived therapy for prostate cancer bone metastasis: Eriocitrin, found in lemons, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 7/April/2017, 11.34 pm
Natural product-derived therapy for prostate cancer bone metastasis: Eriocitrin, found in lemons, inhibits the expression of Monoamine oxidase A (MAOA), inhibits Shh-IL6-RANKL signaling network, suppresses tumor-stromal interactions, reduces prostate cancer metastasis and prolongs survival via up regulation of its target gene, 7/April/2017, 11.34 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes…

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Molecular therapy for ageing-associated diseases: Lithium, a mood stabilizing agent used in the treatment of Bipolar disorder, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 7/April/2017, 11.08 pm
Molecular therapy for ageing-associated diseases: Lithium, a mood stabilizing agent used in the treatment of Bipolar disorder, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 7/April/2017, 11.08 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Natural product-derived therapy for Metastatic cancers: Naringenin, found in grapefruits, among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 7/April/2017, 8.25 am
Natural product-derived therapy for Metastatic cancers: Naringenin, found in grapefruits, among others, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 7/April/2017, 8.25 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Oncostatin M (OSM) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene, 7/April/2017, 6.50 am
Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Oncostatin M (OSM) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene, 7/April/2017, 6.50 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

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Natural product-derived therapy for Allergic rhinitis: α-lipoic acid, found in Broccoli, brussel sprouts, and kali among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 6/April/2017, 11.56 pm
Natural product-derived therapy for Allergic rhinitis: α-lipoic acid, found in Broccoli, brussel sprouts, and kali among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 6/April/2017, 11.56 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: α-lipoic acid, found in Broccoli, brussel sprouts, and kali among others, inhibits GM-CSF, Interleukin…

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Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: γ-Bisabolene, one of the main components of Cardamom, cubeb, oregano, and lemon among others, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 6/April/2017, 8.14 am
Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: γ-Bisabolene, one of the main components of Cardamom, cubeb, oregano, and lemon among others, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 6/April/2017, 8.14 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA…

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