Ideas

Natural product-based therapy for ageing-associated diseases: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 5/April/2017, 7.41 pm
Natural product-based therapy for ageing-associated diseases: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 5/April/2017, 7.41 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: Naringenin, a class of flavonoid found in Citrus fruits, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 5/April/2017, 2.13 pm
Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: Naringenin, a class of flavonoid found in Citrus fruits, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 5/April/2017, 2.13 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA…

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Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Linalool, found in coriander, sweet orange (Citrus sinensis), tomato, oils of rose, neroli, lavender, laurel and sweet basil (Ocimum basilicum) among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 5/April/2017, 1.54 pm
Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Linalool, found in coriander, sweet orange (Citrus sinensis), tomato, oils of rose, neroli, lavender, laurel and sweet basil (Ocimum basilicum) among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 5/April/2017, 1.54 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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Small molecule based-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Trichostatin A, a histone deacetylase inhibitor, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target, 5/April/2017, 6.21 am
Small molecule based-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Trichostatin A, a histone deacetylase inhibitor, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target, 5/April/2017, 6.21 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

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Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: Cucurbitacin E, found abundantly in water melons, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 4/April/2017, 8.14 am
Natural product-derived antiviral therapy against Neuroinvasive West Nile virus: Cucurbitacin E, found abundantly in water melons, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 4/April/2017, 8.14 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA…

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Natural product-derived therapy for Allergic rhinitis: γ-Bisabolene, one of the main components of Cardamom, cubeb, oregano, and lemon among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 4/April/2017, 7.03 am
Natural product-derived therapy for Allergic rhinitis: γ-Bisabolene, one of the main components of Cardamom, cubeb, oregano, and lemon among others, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 4/April/2017, 7.03 am 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: γ-Bisabolene, one of the main components of Cardamom, cubeb, oregano, and lemon among…

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