Ideas

August 25, 2017

Natural product-derived antiviral therapy for HIV virus: Ivermectin (Brand name: Heartguard/Mectizen/Stromectol)  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 25/August/2017, 11.46 pm

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, […]
August 25, 2017

Natural product-derived therapy for heart regeneration and repair: β-Cryptoxanthin, isolated from Satsuma Mandarin, Buah Merah, Papaya, Paparika and among others, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 25/August/2017, 7.53 am

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
August 24, 2017

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A therapeutic mix encompassing Berberine, Gambogic acid, β-Cryptoxanthin (BCX) [BGBCX]  increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via up regulation of its target gene, 25/August/2017, 5.20 am

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 24, 2017

Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of tumor suppressors PDCD4 and PTEN, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 25/August/2017, 4.48 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
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