Ideas

October 16, 2017
Published by admin_auro at October 16, 2017
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Xenon-based PD-1 pathway activation for Pain therapy: Xenon, a general anesthetic,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gen, 16/October/2017, 11.30  pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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October 15, 2017
Published by admin_auro at October 15, 2017
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Natural product-based therapy for Deafness: A therapeutic mix encompassing Withaferin A,  Celastrol, Cholecalciferol  and DIM (WACCAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  and improves hearing loss via up regulation of its target genes, 16/October/2017, 1.04 am

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Deafness: A therapeutic mix encompassing Withaferin A,  Celastrol, Cholecalciferol  and DIM (WACCAD)  increases […]
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October 15, 2017
Published by admin_auro at October 15, 2017
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Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Zinc metallochaperone-1 (ZMC1), Formononetin, Apigenin, EGCG, Chloroquine, Tubascin, Triptolide, Temozolomide, Cholecalciferol, Dehydroleucodine, PEITC, & Linalool  (ZMC1FAECTTTCDPL) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 16/October/2017, 12.33 am

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]
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October 15, 2017
Published by admin_auro at October 15, 2017
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Vitamin/amino acid-based combinatorial therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix encompassing Vitamin-E, Taurine and Vitamin-C (VETAVC) increases REV-ERB and its down stream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 15/October/2017,11.54 pm

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
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