Ideas

Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am
Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am
Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

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Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm
Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014…

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Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am
Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear. This study suggests that…

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Natural product-derived therapy for glucose homeostasis and TIIDM: Lycium barbarum polysaccharide (LBP), isolated from Goji Berry (Wolfberry), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 26/February/2017, 12.37 am
Natural product-derived therapy for glucose homeostasis and TIIDM: Lycium barbarum polysaccharide (LBP), isolated from Goji Berry (Wolfberry), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 26/February/2017, 12.37 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Natural product-derived therapy for Diabetic Kidney disease: Thymoquinone, one of the major constituents of Nigella Sativa, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 26/February/2017, 12.07 am
Natural product-derived therapy for Diabetic Kidney disease: Thymoquinone, one of the major constituents of Nigella Sativa, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 26/February/2017, 12.07 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that “Reducing VEGF-B Signaling Ameliorates…

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