Ideas

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Nanog, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 24/January/2016, 10.53 pm
Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Nanog, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 24/January/2016, 10.53 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of protein that is enriched in cancer stem…

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Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Sprouty-1/2 (SPRY-1/2) and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 24/February/2017, 10.31 pm
Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Sprouty-1/2 (SPRY-1/2) and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 24/February/2017, 10.31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of Sprouty-1/2 (SPRY-1/2). Thereby, it may…

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Natural product-derived therapy for Diabetic Kidney disease: Extracts of Piper betle leaves (PBLs) decrease VEGF-B expression, inhibit lipid accumulation in Podocytes, promote insulin signalling in Podocytes, induce insulin sensitivity, ameliorate renal dysfunction and alleviate diabetic kidney disease via down regulation of its target gene, 24/February/2017, 12.06 pm
Natural product-derived therapy for Diabetic Kidney disease: Extracts of Piper betle leaves (PBLs) decrease VEGF-B expression, inhibit lipid accumulation in Podocytes, promote insulin signalling in Podocytes, induce insulin sensitivity, ameliorate renal dysfunction and alleviate diabetic kidney disease via down regulation of its target gene, 24/February/2017, 12.06 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that “Reducing VEGF-B Signaling Ameliorates…

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Natural product-based therapy for Metabolic diseases: Persimmon tannin extract (PTE) increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene., 24/February/2017, 11.23 am
Natural product-based therapy for Metabolic diseases: Persimmon tannin extract (PTE) increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene., 24/February/2017, 11.23 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published…

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Natural product-derived antiviral therapy for HIV virus: α-Lipoic acid, found in Broccoli, brussel sprouts, and kali among others, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 24/February/2017, 10.58 am
Natural product-derived antiviral therapy for HIV virus: α-Lipoic acid, found in Broccoli, brussel sprouts, and kali among others, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 24/February/2017, 10.58 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, New York, NY 10032,…

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Natural product-derived therapy for Myocardial Infarction: Morin (3,5,7,2′,4′-pentahydroxyflavone), found in Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and leaves of Psidium guajava (common guava), inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 24/February/2017, 6.40 am
Natural product-derived therapy for Myocardial Infarction: Morin (3,5,7,2′,4′-pentahydroxyflavone), found in Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and leaves of Psidium guajava (common guava), inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 24/February/2017, 6.40 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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