Natural product-derived therapy for Metastatic human tumors: Magnolin, one of the main components of herb Magnolia fargesii/Flos, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/February/2017, 10.55 pm
Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published in the 5 January 2017 issue of the […]
Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: BMP4 (Bone Morphogenetic Protein-4) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 10/February/2017, 9.52 pm
Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study was published in the 12 December 2016 issue of Cancer cell (one of the best journals in […]
Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Eriocitrin, Cholecalciferol and ATRA decreases the expression of the CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 10/February/2017, 8.08 am
Introduction: What they say: A study from the Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA shows that “Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.” This study was published in the 6 February 2017 issue of the journal “Nature” [the number 1 journal in […]
Natural product-derived therapy for glucose homeostasis and TIIDM: Celastrol, isolated from herb Thunder God Vine, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 9/February/2017, 10.59 pm
Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]
Natural product-derived anti-ageing therapy: Docosahexaenoic acid (DHA), found in fish oil, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 9/Februay/2017, 10.08 pm
Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA shows that Prolonged Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. This […]
Anti-telomerase cancer therapy: Bergapten (5-methoxy psoralen), found in Bergamot, grapefruit, lemon, and lime, among others, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 9/February/2017, 11.15 am
Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say: In connection with this finding, Dr Boominathan, Founder […]