Ideas

Natural product-derived therapy for Metastatic human tumors: Magnolin, one of the main components of herb Magnolia fargesii/Flos, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/February/2017, 10.55 pm
Natural product-derived therapy for Metastatic human tumors: Magnolin, one of the main components of herb Magnolia fargesii/Flos, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 10/February/2017, 10.55 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102,…

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Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: BMP4 (Bone Morphogenetic Protein-4) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 10/February/2017, 9.52 pm
Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: BMP4 (Bone Morphogenetic Protein-4) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 10/February/2017, 9.52 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Eriocitrin, Cholecalciferol and ATRA decreases the expression of the CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 10/February/2017, 8.08 am
Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Eriocitrin, Cholecalciferol and ATRA decreases the expression of the CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 10/February/2017, 8.08 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA shows that “Synthetic essentiality of chromatin…

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Natural product-derived therapy for glucose homeostasis and TIIDM: Celastrol, isolated from herb Thunder God Vine, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 9/February/2017, 10.59 pm
Natural product-derived therapy for glucose homeostasis and TIIDM: Celastrol, isolated from herb Thunder God Vine, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 9/February/2017, 10.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Natural product-derived anti-ageing therapy: Docosahexaenoic acid (DHA), found in fish oil, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 9/Februay/2017, 10.08 pm
Natural product-derived anti-ageing therapy: Docosahexaenoic acid (DHA), found in fish oil, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 9/Februay/2017, 10.08 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental…

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Anti-telomerase cancer therapy: Bergapten (5-methoxy psoralen), found in Bergamot, grapefruit, lemon, and lime, among others, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 9/February/2017, 11.15 am
Anti-telomerase cancer therapy: Bergapten (5-methoxy psoralen), found in Bergamot, grapefruit, lemon, and lime, among others, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 9/February/2017, 11.15 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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