Ideas

Natural product-derived therapy for glucose homeostasis and TIIDM: 4-Ethyl Catechol, found in herbal medicine Barleria lupulina, and fermented Noni (Morinda citrifolia) juice, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 8/February/2017, 11.51 pm
Natural product-derived therapy for glucose homeostasis and TIIDM: 4-Ethyl Catechol, found in herbal medicine Barleria lupulina, and fermented Noni (Morinda citrifolia) juice, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 8/February/2017, 11.51 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that…

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Molecular therapy for Myocardial Infarction: Long ncRNA CUDR (Cancer up regulated drug resistant) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 8/February/2017, 10.54 pm
Molecular therapy for Myocardial Infarction: Long ncRNA CUDR (Cancer up regulated drug resistant) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 8/February/2017, 10.54 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor Sprouty1 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene, 8/February/2017, 10.23 pm
Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor Sprouty1 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene, 8/February/2017, 10.23 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of metastasis suppressor Sprouty1. Thereby, it may…

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Natural product-based Lifespan extension therapy: Arecoline/Areca nut extract prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/February/2017, 9.25 pm
Natural product-based Lifespan extension therapy: Arecoline/Areca nut extract prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/February/2017, 9.25 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1)…

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Natural product therapy for pulmonary arterial hypertension: EGCG (Epigallocatechin-3-gallate), one of the main components of Green tea, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 8/February/2017, 8.56 am
Natural product therapy for pulmonary arterial hypertension: EGCG (Epigallocatechin-3-gallate), one of the main components of Green tea, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 8/February/2017, 8.56 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General…

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Molecular therapy for Bone disorders: MiR-1827 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 8/February/2017, 8.33 am
Molecular therapy for Bone disorders: MiR-1827 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 8/February/2017, 8.33 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis…

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